4053 WI Institute Medical Research
Assistant Professor of Medicine, Hematology-Oncology
The major research interest in Dr. Rui’s laboratory is the mechanisms of the JAK-STAT signaling pathway in lymphomagenesis. The goal of his research is to discover effective molecular targets in this pathway for therapeutic, diagnostic and prognostic development of human lymphoma. His research team employs a multidisciplinary approach, using biochemistry, RNA interference, next-generation sequencing (including ChIP-seq and RNA-seq), and systems biology methods, to identify JAK1 target genes in this lymphoma and to investigate crosstalk between JAK1 and other signaling pathways, such as NF-kB. Dr. Rui has collaborated with Dr. Shigeki Miyamoto in this area for the past four years, yielding three co-authored publications in Experimental Cell Research, Oncogene, and Molecular Cancer Research.