608-265-4262 (office); 608-265-9283 (lab)
3158 UW Med Foundation Centennial Bldg
Department Chairperson and Professor of Pathology and Laboratory Medicine
My research focuses on the role of heparan sulfate proteoglycans (HSPGs) in tumorigenesis and cancer progression. HSPGs are hybrid molecules, which consist of core proteins and heparin-like polysaccharide domains. HSPGs are found in abundance on cell surfaces and in the extracellular matrix. One project focuses on the role of the HSPG syndecan-1 in stromal fibroblasts of breast carcinomas. The goal is to decipher the mechanisms by which stromal syndecan-1 stimulates breast carcinoma growth and invasion. A separate project aims at identifying the mechanisms by which the HSPG glypican-1 regulates cell cycle progression in brain tumor cells.